8:30 - 9:00 AM
 

9:00 AM

Welcome & Overview of Meeting

9:15 - 10:30 AM



 

CELLULAR AND MOLECULAR MECHANISMS IN FIBROSIS Chairs: Dolores Barrachina (University of Valencia) & Jordi Gracia-Sancho (IDIBAPS, Barcelona)

9:15-9:53 AM: An INTESTINAL perspective. Gerhard Rogler (University Hospital Zurich)

9:53-10:30 AM: A LIVER perspective. Frank Tacke (Charité Universitätsmedizin Berlin)

10:30 -11:00 AM  

Coffee break
 

11:00 - 1:00 PM

                                      





 

FACTORS INFLUENCING THE DEVELOPMENT OF FIBROSIS

Chairs: Sara Calatayud (University of Valencia) & Manon Wilderberg (University of Amsterdam)

11:00-11:30 AM: Microbiota. Rubén Francés (FISABIO-Hospital General Universitario de Alicante)

11:30-12:00 AM: Vascular biology. Jordi Gracia (IDIBAPS, Barcelona)

12:00-12:30 PM: Epithelial-to-mesenchymal transition. Ángela Nieto (Instituto de Neurociencias de Alicante)

12:30-1:00 PM: Fibrosis regression: the example of the antiretroviral Rilpivirine. Ana Blas-García (University of Valencia)

1:00 – 2:30 PM

Lunch 

 

2:30 – 4:00 PM
 

FROM BENCH TO BEDSIDE

Chairs: Marta M. Boscá-Watts (Hospital Clínico Universitario de Valencia) & Juan Sastre (University of Valencia)

2:30-2:53 PM: Fibrosis in Crohn’s disease. Manon Wildenberg (University of Amsterdam)

2:53-3:15 PM: Experimental models of murine intestinal fibrosis. Jesús Cosín-Roger (FISABIO, Valencia)

3:15-3:38 PM: Traslational research in liver fibrosis. Salvador Benlloch (Hospital Universitario La Fe, Valencia)

3:38-4:00 PM: Experimental models of murine liver fibrosis. Javier Cubero (Universidad Complutense, Madrid)

4:00 – 4:30 PM

Coffee break
 

4:30 – 5:30 PM









 

SPECIFIC TOPICS

Chairs: Ana Blas-García (University of Valencia) & Rubén Francés (FISABIO-Hospital General Universitario de Alicante)

4:30-4:50 PM: Exosomes and omics. Juan Manuel Falcón (CICbioGUNE, Bilbao)

4:50-5:10 PM: Advances in in vitro models of intestinal fibrosis. Azucena Salas (Hospital Clínic, Barcelona)

5:10-5:30 PM: Advances in in vitro models of liver fibrosis. Novel 3D cell culture systems for new target identification and drug development. Krista Rombouts (University College London)
 

6:00 – 8:00 PM

Tour of the city

8:00 PM

Drinks and canapés

9:00 - 11:00 AM

 

ORAL PRESENTATIONS

Chairs: Nadezda Apostolova (University of Valencia) & Moises Diago (Hospital General Universitario de Valencia)

9:00 – 9:12 AM: A novel hybrid murine model of BASH with rapid progression to advanced fibrosis. Raquel Benedé-Ubieto (Universidad Complutense de Madrid)

9:12 – 9:24 AM: Proteomic profiling of hepatic stellate cell differentiation from induced pluripotent stem cells: new tools to understand liver development and fibrosis. Raquel A. Martínez García de la Torre (IDIBAPS, Barcelona)

9:24 – 9:36 AM: Role of Notch Pathway in the induction of fibrosis in Crohn's disease. Jorge Marín-Aracil (University of Valencia)

9:36 – 9:48 AM: Inhibition of CCL2/CCR2 signaling promotes Rilpivirine-induced anti-fibrotic and anti-inflammatory effects in liver diseases. Ángela Moragrega (University of Valencia)

9:48 – 10:00 AM: Fibroblast Growth Factor 21 is induced in non-alcoholic fatty liver disease. Rocío Gallego-Durán (Instituto de Biomedicina de Sevilla)

10:00 – 10:12 AM: Chemokine network transcriptional regulation by biologic monotherapy in ileum of patients with Crohn’s disease. Raquel Linares (Universidad Miguel Hernández)

10:12 – 10:24 AM: Hepatocyte derived microRNAs embedded in extracellular vesicles negatively impact on the liver sinusoidal endothelium in chronic liver disease. Laia Abad-Jordá (IDIBAPS, Barcelona)

10:24 – 10:36 AM: Defective proteolytic processing of collagen in macrophages enhances liver fibrosis. Paloma Ruiz-Blázquez (Instituto de Investigaciones Biomédicas de Barcelona)

10:36 – 10:48 AM: Ileal transcriptomic changes in complicated Crohn´s disease reveals extracellular matrix organization, inflammation and cell activation signature expression. Marta Seco-Cervera (FISABIO-Hospital Dr. Peset)

11:00 - 11:30 AM

Coffee Break
 

11:30 - 1:30 PM









 

THERAPEUTIC APPROACHES TO FIBROSIS

Chair: Fernando Gomollón (Hospital Clínico Universitario “Lozano Blesa”, Zaragoza) & Javier Ampuero Herrojo (IBiS, Campus Hospital Universitario Virgen del Rocío, Sevilla)

11:30-12:00 AM: Pharmacology of fibrosis. Sara Calatayud (University of Valencia)

12:00-12:30 PM: Management of liver fibrosis. Jaume Bosch Genover (University of Bern and IDIBAPS, Barcelona)

12:30-1:00 PM: Advanced liver fibrosis in HCV-infected patients. Marina Berenguer (Hospital Universitario La Fe, Valencia) 

1:00-1:30 PM: Epidemiology and management of fibrosis in Crohn’s disease. Eugeni Domènech (Hospital Universitari Germans Trias i Pujol, Badalona)

1:30 -1:45 PM